Ceramide turnover in GtoPdb v.2023.1

Ceramide kinase and ceramide-1-phosphate.

It has been over a decade since the sphingolipid ceramide-1-phosphate (C1P) was described. Until recently, only sparse reports on possible biological functions for this lipid have been published. A large number of reports have now surfaced demonstrating distinct biological mechanisms regulated by C1P produced from ceramide kinase (CERK). In the following methods chapter, the methodologies for e...

Detergent-resistant, ceramide-enriched domains in sphingomyelin/ceramide bilayers.

When cell membranes are treated with Triton X-100 or other detergents at 4 degrees C, a nonsolubilized fraction can often be recovered, the "detergent-resistant membranes", that is not found when detergent treatment takes place at 37 degrees C. Detergent-resistant membranes may be related in some cases to membrane "rafts". However, several basic aspects of the formation of detergent-resistant m...

Ceramide in the prostate

The nomenclature for the serine/threonine protein phosphatases was established by Professor Sir Philip Cohen over 30 years ago. (1) At that time protein phosphatase 1 was known to have two small inhibitory proteins (I-1 and I-2) and be regulated by sub-cellular location whereas no protein inhibitor had yet been discovered for the related multi-subunit phosphatase PP2A. That paradigm subsequentl...

Mitochondrial Ceramide in Stroke

Phenomenological Analysis of Employees’ Turnover Experience in a Public Organization

Purpose: This study aims at investigating the experiences of employees who have left their jobs in a state-owned organization in the city of Tehran. Methodology: The sample of this study consisted of 10 members of this organization who have left it voluntarily between 2016 and 2020 and semi-structured interviews were used to collect data. To analyze data, the experimental phenomenological appr...